Entering the spotlight: hepatitis B surface antigen–specific B cells
نویسندگان
چکیده
منابع مشابه
Surface protein mutations in chronic hepatitis B patients who received hepatitis B vaccine therapy
Objective (s):The aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis B surface antigen (HBsAg)-positive chronic hepatitis B virus (HBV) patients. Materials and Methods: 16 patients received the HBV vaccine and another 16 individuals from the control group did not. The surface gene was amplified and directly sequenced from samples...
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The genome of HB V virus of serotype ayw cloned in pBR322 and expression shuttle vector p YES2 were used for construction of the HBsAg chimeric genes and their expression in Saccharomyces cerevisiae. Two recombinant plasmids were constructed. One of them contained the coding sequences for the major polypeptide of surface antigen. Another construct carried the major polypeptide with the pre-S2 a...
متن کاملPrevalence of hepatitis B surface antigen among refugees entering the United States between 2006 and 2008.
The Centers for Disease Control and Prevention recommends hepatitis B surface antigen (HBsAg) testing to identify chronic hepatitis B virus infection for foreign-born persons from countries or regions with HBsAg prevalence of >or=2%. However, limited data exist to indicate which countries meet this definition. To address this data gap, we estimated the HBsAg prevalence among refugees entering t...
متن کاملThe Study of Cerumen Hepatitis B Infection in Chronic Hepatitis B Patients by Real-Time PCR
Introduction: The hepatitis B is a viral infection that causes a big problem globally. About 2 billion people worldwide are infected and there are now about 400 million HBV-DNA carriers around the world. HBV infection is the ninth cause of death worldwide and infects about 350 million new cases each year in the world. HBV-DNA can be spotted in different body secretions and fluids, including se...
متن کاملSTUDIES ON HEPATITIS B VACCINES
HBs vaccines were prepared by three different methods: 1) Heat inactivation (Krugman, et.al 1971)2) Ammonium sulphate precipitation followed by column chromatography (Sephadex G-200) 3) PEG-6000 (polyethylene glycol) precipitation followed by column chromatography using Sephadex G-200. Their efficacy was studied in guinea pigs, and the results compared with commercial Japanese vaccine (Gr...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2018
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci124098